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Using genetic sequencing, University of California San Diego School of Medicine researchers have identified a principal cellular player controlling HIV reproduction in immune cells which, when turned off or deleted, eliminates dormant HIV reservoirs. HIV spreads through certain bodily fluid attacking the immune system and preventing the body from fighting off infections. If left untreated, the virus leads to the disease AIDS. Antiretroviral therapy is used to prevent and treat HIV, allowing patients to live long and healthy lives. However, the medication does not cure patients. Instead, the virus remains inactive in the body. If therapy is discontinued, the virus awakens and multiplies rapidly. In a study published online on September 24, in the journal mBio , Rana and colleagues report the first genome-wide expression analysis of long noncoding RNA lncRNA in HIV-infected macrophages — specialized immune cells that promote tissue inflammation, stimulate the immune system and rid the body of foreign debris. In general, lncRNAs do not encode the recipe for proteins the way other RNAs do, but instead help control which genes are turned “on” or “off” in a cell. Additional research to confirm these effects in animal models will be performed.

A Community-Based Study of Barriers to HIV Care Initiation

Quantitative analyses revealed significant changes after diagnosis, including reductions in total partners and decreases in the proportion of unprotected sex acts occurring with uninfected partners serosorting. Qualitative findings indicated that these changes were motivated by concerns about infecting others. However, participants were less successful at increasing the frequency with which they used condoms.

We further analyzed data from recently HIV-infected MSM in the network who of California, San Diego (UCSD) HIV screening centers in central San Diego An estimated date of infection (EDI) was calculated using a previously reported.

Compared to those who aren’t on Grindr, cisgender gay and bisexual men on the app were definitely taking more sexual risks that made them more likely to contract HIV and sexually transmitted infections STIs — but they were also more likely to use pre-exposure prophylaxis PrEP or be open to using PrEP, according to new research. Men on Grindr did in fact tend to have higher rates of chlamydia and gonorrhea than men who weren’t on Grindr, but those on the hook-up app also had fewer new HIV diagnoses.

The study findings were released at the IDWeek conference on Oct. The researchers surveyed 1, men who have sex with men. The men filled out questionnaires; researchers found that 1, men Researchers also found that the men who used Grindr had engaged in higher-risk sex acts, including a higher number of male partners and more instances of condomless sex in the past year.

When it came to actual STI or HIV risk, researchers found men on Grindr were more likely to test positive for chlamydia or gonorrhea 8. Grindr users were more likely to take PrEP The debates about whether or not hook-up apps like Grindr are helping fuel HIV and other STIs among gay and bisexual men won’t likely end soon.

Thomas Guerra

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A San Diego man accused of knowingly spreading HIV to unwitting partners is still active on the dating app Grindr and may be using an alias, an ex-boyfriend tells NBC 7. Thomas Miguel Guerra, 29, has pleaded not guilty to a misdemeanor charge in connection with what San Diego City Attorney officials say was an ongoing plan to knowingly spread HIV.

Already poz. Poor Sucka,” the text read. The ex-boyfriend, who did not want to be identified, said he is concerned he may be a victim. It’s sad,” he said. The city’s criminal case against Guerra is based on the claims of another ex-boyfriend of Guerra. Guerra tested positive at that time, according to the arrest warrant. He has pleaded not guilty to the charge against him. The DA’s office declined to issue a felony warrant and referred the case to the City Attorney’s office to be handled as a misdemeanor.

Guerra has been charged with one count of violating a section of the Health and Safety Code that states that anyone with a communicable disease who willfully exposes himself to another person is guilty of a misdemeanor. Skip to content. San Diego County Jun

MSM on Dating App Grindr More Open to HIV Prevention

When Larry Pike came down with a cough and a mild fever in early March, the year-old was concerned. COVID was in the news. He called his doctor, who knows him well. Because for 22 years, Pike has also been living with HIV. On March 10, his illness took a turn for the worse. He woke up to a severe headache and a higher fever.

Edward R. Cachay, MD in San Diego, CA | Front Street. He is a part of UC San Diego Health’s Owen Clinic, one of the nation’s outstanding primary care centers for HIV positive men and women. Dr. Cachay heads Date Joined Staff.

Sexual partner concurrency is common among men who have sex with men MSM and may increase the probability of HIV transmission during recent acute or early infection. Observational study integrating behavioral, clinical, and molecular epidemiology. We further analyzed data from recently HIV-infected MSM in the network who provided information on up to three sexual partners in the past three months, including the timing of intercourse with each partner. Concurrency was defined as sexual partners overlapping in time.

Logistic and negative binomial regression were used to investigate the link between concurrency and HIV transmission network characteristics i. Our findings provide empirical evidence consistent with the hypothesis that concurrency facilitates HIV transmission during recent infection. Acute and early HIV infection, characterized by a high viral load and increased infectiousness [ 1 ], contribute disproportionately to HIV transmission [ 2 ].

Concurrency reduces the time between sexual partner acquisition, and thus may facilitate HIV transmission by increasing the probability of exposing an uninfected partner during the highly infectious period following HIV acquisition from an infected concurrent partner [ 4 ]. Simulation studies have demonstrated the impact of concurrency on the spread of HIV during acute and early infection [ 5 – 7 ]; however, most epidemiologic studies to date have not been appropriately designed to empirically evaluate the role of concurrency [ 8 , 9 ].

Advances in molecular epidemiologic methods support HIV transmission network inference through the identification of HIV-infected individuals with genetically related viruses [ 10 – 12 ]. As such, research that combines behavioral, clinical, and molecular epidemiology to assess the relationship between concurrency and HIV transmission network characteristics i.

To investigate the influence of concurrency on HIV transmission, we examined the association between concurrency and HIV transmission network characteristics using behavioral, clinical, and molecular epidemiologic data from MSM with recent i. Individuals with detuned results consistent with early infection or positive NAAT results were classified as having recent HIV infection.

Pantry Service

The heatwave is fading, but greater San Diego will stay warmer than normal. Overnight temperatures are unlikely to fall below 70 in most of the region. Alfredo Montano, 32, is accused in the June 5 death of Sean Nixon, 44, who prosecutors say was strangled with a strap from a marijuana grow tent.

Thomas Miguel Guerra (born February 23, ) is an American landscape architect who Guerra’s ex-boyfriend filed a complaint against him with San Diego police in August, pleaded no contest to a misdemeanor charge of violating a California health code by failing to tell his former partner he was HIV positive.

Either your web browser doesn’t support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Incidence was stable from to 0. Among 43 successfully treated patients, 3 were reinfected. Viral hepatitis was the seventh leading cause of mortality worldwide in , with half of these deaths attributable to hepatitis C virus HCV [ 1 ].

Additionally, high rates of HCV reinfection have been reported in Europe 5—10 times the primary incidence [ 18—20 ]. Demographic data on age and ethnicity were collected. Results were censored at the end of to reduce the bias arising from the selection criteria requiring 2 HCV tests, resulting in lower total person-years in and , given a median testing interval interquartile range [IQR] of 1.

Governor Signs Bill Modernizing California HIV Laws

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Re: What Dating Is Like When You’re HIV-Positive

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